| Bioactivity | CZY43 is a HER3 degrader. CZY43 can effectively induce HER3 degradation in a dose- and time-dependent manner in breast cancer SKBR3 cells. CZY43 potently inhibits HER3-dependent signaling and cancer cell growth and outperforms Bosutinib (HY-10158)[1]. |
| Formula | C42H53Cl2N5O3 |
| Molar Mass | 746.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen Z, et al. Discovery of CZY43 as a new small-molecule degrader of pseudokinase HER3. Eur J Med Chem. 2025 Jan 10;285:117258. |