| Bioactivity | CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity[1]. |
| Target | IC50: 1.28 nM (Wild-type LRRK2) and 1.85 nM (G2019S LRRK2) |
| Name | CZC-54252 hydrochloride |
| CAS | 1784253-05-9 |
| Formula | C22H26Cl2N6O4S |
| Molar Mass | 541.45 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. |
CZC-54252 hydrochloride
CAS: 1784253-05-9 F: C22H26Cl2N6O4S W: 541.45
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2
Data collection：peptidedb@qq.com
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