CYP19A1/CYP11B2-IN-1_product_DataBase

Bioactivity	CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC50s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer[1].
Invitro	CYP19A1/CYP11B2-IN-1 (Compound X21) (0.001-100 μM, 24 h) 对 MCF-7 和 MDA-MB-231 细胞都显示出时间和浓度依赖性的增殖抑制作用[1]。CYP19A1/CYP11B2-IN-1 (700 nM, 24 h) 显著抑制 MCF-7 细胞中 mTOR 的磷酸化，从而负调控 PI3K / Akt / mTOR 轴[1]。CYP19A1/CYP11B2-IN-1 (20-30 μM) 对hERG和Nav1.5无明显抑制作用，这表明其对心脏无毒性[1]。 0 --> CYP19A1/CYP11B2-IN-1 相关抗体: Cell Proliferation Assay[1] Cell Line:
Name	CYP19A1/CYP11B2-IN-1
CAS	183500-36-9
Formula	C12H11N3O
Molar Mass	213.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tinivella A, et al. Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. ACS Pharmacology & Translational Science. 2023 Nov 23.

PeptideDB