| Bioactivity | CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2]. | ||||||
| Invitro | CYN 154806 TFA inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 TFA also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively)[2]. | ||||||
| Name | CYN 154806 TFA | ||||||
| CAS | 2828432-46-6 | ||||||
| Sequence | Ac-Phe(4-NO2)-Cys-Tyr-Trp-Lys-Thr-Cys-Tyr-NH2 (Disulfide bridge: Cys2-Cys7) | ||||||
| Shortening | Ac-F(4-NO2)CYWKTCY-NH2 (Disulfide bridge: Cys2-Cys7) | ||||||
| Formula | C58H69F3N12O16S2 | ||||||
| Molar Mass | 1311.36 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
CYN 154806 TFA
CAS: 2828432-46-6 F: C58H69F3N12O16S2 W: 1311.36
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values
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