| Bioactivity | CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1]. | ||||||||||||
| Invitro | SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates[1]. | ||||||||||||
| Name | CYM 9484 | ||||||||||||
| CAS | 1383478-94-1 | ||||||||||||
| Formula | C27H31N3O3S2 | ||||||||||||
| Molar Mass | 509.68 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Mittapalli GK, et al. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3916-20. |