CYB210010_product_DataBase

Bioactivity	CYB210010 is an orally bioavailable, long-acting serotonin 5-HT2 receptor agonist that selectively targets 5-HT2A and 5-HT2C receptors (EC50: 4.1 n, 7.3 nM). CYB210010 can enter the central nervous system, cause a head twitch response (HTR), and is not prone to behavioral tolerance during chronic administration[1].
In Vivo	CYB210010 具有一定的口服生物利用度，可顺利进入中枢神经系统，与额叶皮层 5-HT2A 受体结合，并增加额叶皮层神经可塑性相关基因的表达[1]。CYB210010 (0.1-3 mg/kg; sc; 单剂量) 会引起小鼠的头部抽搐反应 (HTR)，并且可以以阈值剂量亚慢性给药，而不会产生行为耐受性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2762568-47-6
Formula	C11H15ClF3NO2S
Molar Mass	317.76
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Varty GB, et al. Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT2 Receptor Agonist. J Med Chem. 2024 Apr 25;67(8):6144-6188.

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