| Bioactivity | CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has acceptable stability (t1/2 = 77.1 min) in mouse serum and exhibits anti-inflammatory activity in mouse edema model[1]. |
| In Vivo | CXCR4 modulator-2 (10 mg/kg; IP; single dosage) significantly reduces the edema weights (∼50%) in the lesion and decreases the expression of CXCR4s[1]. Animal Model: |
| Name | CXCR4 modulator-2 |
| CAS | 2488943-55-9 |
| Formula | C21H32N8O2 |
| Molar Mass | 428.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Oum YH, et al. Discovery of novel aminopiperidinyl amide CXCR4 modulators through virtual screening and rational drug design. Eur J Med Chem. 2020;201:112479. |
CXCR4 modulator-2
CAS: 2488943-55-9 F: C21H32N8O2 W: 428.53
CXCR4 modulator-2 (compound Z7R) is a highly potent CXCR4 modulator with an IC50 value of 1.25 nM. CXCR4 modulator-2 has
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