| Bioactivity | CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2]. | ||||||||||||
| Invitro | CX614 (100 μM) 在 HEK293 细胞中，促进谷氨酸表观亲和力并增加谷氨酸诱发的内向电流，增加 3.5 和 10 mM 的谷氨酸反应峰值[1]。 | ||||||||||||
| In Vivo | CX614 (1 or 10 mg/kg, i.p., twice a day) 明显增加 P5 小鼠海马和皮层的 BDNF mRNA，证实了 AMPA 受体的正向异生调节剂对海马 BDNF mRNA 水平的上调作用[2]。 | ||||||||||||
| Name | CX614 | ||||||||||||
| CAS | 191744-13-5 | ||||||||||||
| Formula | C13H13NO4 | ||||||||||||
| Molar Mass | 247.25 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wei Dai, et al. The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents. Front Pharmacol. 2019 Feb 19;10:105. [2]. Eleni Dicou, et al. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res. 2003 Apr 25;970(1-2):221-5. |