| Bioactivity | CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1]. |
| Invitro | CW0134 (10 nM-10 μM) 抑制 Jurkat 细胞中 IL-2 的表达 (6 h) 和 Jurkat 的细胞活力 (24 h)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CW0134 相关抗体: Cell Viability Assay[1] Cell Line: |
| CAS | 1076235-18-1 |
| Formula | C11H7ClF3N3O2 |
| Molar Mass | 305.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25. |
CW0134
CAS: 1076235-18-1 F: C11H7ClF3N3O2 W: 305.64
CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcript
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