| Bioactivity | CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion[1][2][3]. |
| Name | CW 008 |
| CAS | 1134613-19-6 |
| Formula | C21H14F2N6O2 |
| Molar Mass | 420.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nooshin AMINI, et al. Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons. Patent, WO2023075913A1. [2]. Patrick Soon-Shiong. Patient treatment via teratogenic pharmaceutical compounds. Patent, WO2016176675A2. [3]. Kim JM, et al. An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J Cell Physiol. 2013 Mar;228(3):617-26. |