| Bioactivity | CVRARTR is an antagonist for programmed cell death ligand-1 (PD-L1) with KD of 281 nM. CVRARTR induces the internalization of PD-L1 and downregulates PD-L1 on the cell surface. CVRARTR restores cytokine secretion and T cell proliferation in cell CT26. CVRARTR exhibits antitumor efficacy against in CT26 homograft mouse model[1]. |
| CAS | 2349354-64-7 |
| Sequence | Cys-Val-Arg-Ala-Arg-Thr-Arg |
| Shortening | CVRARTR |
| Formula | C33H64N16O9S |
| Molar Mass | 861.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gurung S, et al., Phage display-identified PD-L1-binding peptides reinvigorate T-cell activity and inhibit tumor progression. Biomaterials. 2020 Jul;247:119984. |
CVRARTR
CAS: 2349354-64-7 F: C33H64N16O9S W: 861.03
CVRARTR is an antagonist for programmed cell death ligand-1 (PD-L1) with KD of 281 nM. CVRARTR induces the internalizati
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