| Bioactivity | CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia[1]. |
| Invitro | CVN293 (0.05、0.5、5 μM) 对 NLRP3 炎症小体介导的 LPS 引发的小鼠小胶质细胞产生 IL-1β 具有浓度依赖性抑制作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CVN293 相关抗体: |
| In Vivo | Pharmacokinetic Parameters of CVN293 in male Sprague-Dawley rat, dog and cynomolgus monkey[1]. |
| CAS | 2815296-08-1 |
| Formula | C14H10FN7O |
| Molar Mass | 311.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Roland W. Bürli, et al.Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment. ACS Med. Chem. Lett. 2024. |