CV122_product_DataBase

Bioactivity	CV122 is a potent heparanase inhibitor with an IC50 value of 2.97 µM. CV122 inhibits proinflammatory cytokines that can be used for sepsis research[1].
Invitro	CV122 (50 µM) 可显著抑制 LPS 刺激巨噬细胞后的肝素酶水平[1]。CV122 (50 µM) 可有效抑制人脐静脉内皮细胞 (HUVEC) 中的肝素酶活性，保护细胞表面糖萼结构，并降低粘附分子的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CV122 相关抗体:
In Vivo	CV122（20-40 mg/kg；皮下注射；一次）可显著降低全身促炎细胞因子水平，防止器官损伤，提高活力，有效保护小鼠免于脓毒症引起的死亡。从机制上讲，CV122 抑制肝素酶活性，降低其在肺中的表达，保护肺组织的糖萼结构[1]。CV122（20 mg/kg）可有效保护小鼠免于克里米亚-刚果出血热病毒 (CCHFV) 感染引起的器官损伤和死亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1648566-65-7
Formula	C31H42N3Na11O52S9
Molar Mass	1830.13
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Danyang Wang, et al. A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm. Adv Sci (Weinh). 2024 May 29:e2403337.

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