| Bioactivity | CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer[1]. | ||||||||||||
| Invitro | CTX-0294885 is a kinase capture tool in large-scale kinome profiling experiments, with 185 kinases identified as total protein, and 179 identified from TiO2 enrichment for phosphopeptides in MDA-MB-231 cells (by quantitative MS)[1].CTX-0294885 captures all members of the AKT family that is not identified from previous studies using other kinase capture reagents[1]. | ||||||||||||
| Name | CTX-0294885 | ||||||||||||
| CAS | 1439934-41-4 | ||||||||||||
| Formula | C22H24ClN7O | ||||||||||||
| Molar Mass | 437.93 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Zhang L, et al. Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling. J Proteome Res. 2013 Jul 5;12(7):3104-16. |
CTX-0294885
CAS: 1439934-41-4 F: C22H24ClN7O W: 437.93
CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all
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