| Bioactivity | CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry[1]. |
| Target | IC50:6.88 nM (CTSL).IC50:347.6 nM (CAPN1). |
| CAS | 2410075-64-6 |
| Formula | C34H40N4O6 |
| Molar Mass | 600.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xie X, et al. Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal Transduct Target Ther. 2024 Mar 6;9(1):54. |
CTSL/CAPN1-IN-2
CAS: 2410075-64-6 F: C34H40N4O6 W: 600.70
CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347
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