| Bioactivity | CTL-12 is an inhibitor of fatty acid synthase (FASN) (IC50: 2.5 μM) and can induce apoptosis. CTL-12 blocks the cell cycle in the Sub-G1/S phase, upregulates the expression of caspase-9 and the apoptosis marker Bax, and downregulates the anti-apoptotic marker Bcl-xL. CTL-12 inhibits de novo lipogenesis, blocks the metabolic demands of tumor cells, and is commonly used in breast and colorectal cancer research[1]. |
| Target | IC50: 2.5 μM (FASN) |
| Name | CTL-12 |
| Formula | C22H21ClN4O4 |
| Molar Mass | 440.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Singh S, et al. Design, synthesis, and anticancer activity of some novel 1H-benzo [d] imidazole-5-carboxamide derivatives as fatty acid synthase inhibitors[J]. Bioorganic Chemistry, 2023: 106658.. . . |