Bioactivity | CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model |
CAS | 787504-88-5 |
Formula | C10H13N3O5 |
Molar Mass | 255.23 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |