| Bioactivity | CSI86 is a MYC-targeting PROTAC degrader with antiproliferative activity (IC50: 13-18 μM)[1]. CSI86 is composed of MYC inhibitor (red part) CSI118 TFA (HY-169379), E3 ligase ligand (blue part) VH032 (HY-120217), and PROTAC linker (black part) Succinic anhydride (HY-79369). The conjugate composed of E3 ligase ligand and linker is (S,R,S)-CO-C2-acid (HY-131866). |
| Formula | C48H50F9N7O7S |
| Molar Mass | 1040.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Siokatas C, et al. Developing MYC Degraders Bearing the Von Hippel–Lindau Ligand to Target the “Undruggable” MYC[J]. ACS Pharmacology & Translational Science, 2024. |