CSF1R-IN-23_product_DataBase

Bioactivity	CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1].
Invitro	CSF1R-IN-23 (0-10 μM, 30 min) 抑制细胞 RAW264.7 和小胶质细胞 EOC20 中 CSF1R 的自磷酸化，没有明显的细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CSF1R-IN-23 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	CSF1R-IN-23 (0.5 mg/kg，腹腔注射，每两天一次，共四次)可改善 C57BL/6J 小鼠模型中脂多糖 (HY-D1056) 诱导的神经炎症[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2935480-17-2
Formula	C27H37N3O2
Molar Mass	435.60
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Baek J, et al., Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. J Med Chem. 2024 Apr 11;67(7):5699-5720.

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