Bioactivity | CSD-CH2(1,8)-NH2 is a selective and competitive KOR antagonist (Ki: 6.8 nM). CSD-CH2(1,8)-NH2 inhibits calcium mobilization in DRG neurons. CH2(1,8)-NH2 antagonizes the antinociceptive effect of U50,488. CSD-CH2(1,8)-NH2 can be used for research of neuropsychiatric disorders[1]. |
Target | Ki: 6.8 nM (KOR) |
Name | CSD-CH2(1,8)-NH2 |
Formula | C76H125N25O15S2 |
Molar Mass | 1693.09 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Muratspahić E, et al. Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. J Med Chem. 2023 Sep 14;66(17):11843-11854. |