| Bioactivity | CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1]. |
| Invitro | CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively[1]. CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)[1].CS1 (0-20 µM) shows antiproliferation activity in cancer cells[1].CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase[1].CS1 (2.5, 5, 10 µM) induces cell apoptosis[1].CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | CS1 |
| CAS | 1448009-94-6 |
| Formula | C16H12O3 |
| Molar Mass | 252.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |