CS-6253 TFA_product_DataBase

Bioactivity	CS-6253 TFA is the TFA salt form of CS-6253 (HY-P6306). CS-6253 TFA is an agonist for ATP-binding cassette 1 (ABCA 1). CS-6253 TFA improves the amyloid-β42/40 ratio, and affects lipoprotein metabolism in plasma. CS-6253 TFA generates cholesterol-rich high-density lipoprotein (HDL) particles, and induces the release of microparticles[1][2].
Sequence	Glu-Val-{Cit}-Ser-Lys-Leu-Glu-Glu-Trp-Leu-Ala-Ala-Leu-{Cit}-Glu-Leu-Ala-Glu-Glu-Leu-Leu-Ala-Arg-Leu-Lys-Ser
Shortening	EV-{Cit}-SKLEEWLAAL-{Cit}-ELAEELLARLKS
Formula	C136H228N36O43.xC2HF3O2
Molar Mass	3055.48 (free base)
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Noveir SD, et al., Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 Jun 24;14(1):87. [2]. Hafiane A, et al., Genest J. ABCA1 Agonist Mimetic Peptide CS-6253 Induces Microparticles Release From Different Cell Types by ABCA1-Efflux-Dependent Mechanism. Can J Cardiol. 2019 Jun;35(6):770-781.

PeptideDB