| Bioactivity | CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example 1, has an IC50 of ≤10 nM. CRTh2 antagonist 2 can be used in research of androgenic alopecia[1]. |
| Target | IC50: ≤10 nM (CRTh2) |
| Invitro | CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) protein, also known as GPR44, is a G-protein coupled receptor (GPCR) which is amongst other ligands most strongly activated by prostaglandin D2 (PGD2). PGD2 is a product of prostaglandin D2 synthase (PTGDS)[1]. |
| Name | CRTh2 antagonist 2 |
| CAS | 780763-95-3 |
| Formula | C26H23ClN4O3 |
| Molar Mass | 474.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Andreas Schnapp, et al. Pyrimidine compounds for treating hairloss. US20140148470A1. |
CRTh2 antagonist 2
CAS: 780763-95-3 F: C26H23ClN4O3 W: 474.94
CRTh2 antagonist 2 is selective and potent CRTH2 antagonist extracted from patent US20140148470A1, compound Example
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