| Bioactivity | CRT0063465 is a Ligand of HumanPGK1andStress Sensor DJ1, with theKdof 24 μM ofPGK1. CRT0063465 modulates the shelterin complex compositionand telomere Length[1]. |
| In Vivo | CRT0063465 (10, 100 nM，最长 84 天) 阻断低血糖 TCT116 细胞的端粒缩短[1]。CRT0063465 (10 nM, 1周) 调节非应激条件下 HCT116 细胞中庇护蛋白复合物的组成[1]。CRT0063465 (100 nM, 长达 100 h) 对 Bleomycin (HY-17565) 诱导的 A2780 细胞毒性具有保护作用[1]。 |
| Name | CRT0063465 |
| Formula | C17H16BrN3O2 |
| Molar Mass | 374.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bilsland AE, et al. A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation. Neoplasia. 2019;21(9):893-907. |