| Bioactivity | CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion[1]. CRN04894 binds to human or rat MC2R with KB values of 0.34 nM and 0.23 nM, respsectively[1]. |
| In Vivo | CRN04894 (compound 17h) (3, 30 mg/kg; 口服; 单剂量) 在 ACTH 刺激的雄性大鼠模型中，呈剂量依赖性降低了皮质酮的分泌水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2392970-97-5 |
| Formula | C33H42F3N5O3 |
| Molar Mass | 613.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim SH, et al. Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist. ACS Med Chem Lett. 2024 Mar 19;15(4):478-485. |
CRN04894
CAS: 2392970-97-5 F: C33H42F3N5O3 W: 613.71
CRN04894 (compound 17h) is an orally active MC2R antagonist that demonstrates in vivo efficacy in rat model of adrenocor
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