| Bioactivity | CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4, 14, 11, 15, 7, and 20 nM respectively. CRA-026440 shows antitumor and antiangiogenic activities[1]. |
| Invitro | CRA-026440 对 HUVEC 内皮细胞具有抗增殖作用，GI50 值为 1.41 μM[1]。CRA-026440（0.1-10 μM；18 小时）导致乙酰化组蛋白和乙酰化微管蛋白的积累，从而抑制肿瘤细胞生长并诱导细胞凋亡[1]。CRA-026440（0.1-10 μM；5 天）以剂量依赖性方式抑制离体血管生成[1]。 Western Blot Analysis[1] Cell Line: |
| Name | CRA-026440 |
| CAS | 847460-34-8 |
| Formula | C23H24N4O4 |
| Molar Mass | 420.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
CRA-026440
CAS: 847460-34-8 F: C23H24N4O4 W: 420.46
CRA-026440 is a potent, broad-spectrum HDAC inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, H
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