CRA-026440 hydrochloride_product_DataBase

Bioactivity

CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities[1].

Invitro

CRA-026440 hydrochloride 对 HUVEC 内皮细胞具有抗增殖作用，GI50 值为 1.41 μM[1]。CRA-026440 hydrochloride（0.1-10 μM；18 小时）导致乙酰化组蛋白和乙酰化微管蛋白的积累，从而抑制肿瘤细胞生长并诱导细胞凋亡[1]。CRA-026440 hydrochloride（0.1-10 μM；5 天）以剂量依赖性方式抑制离体血管生成[1]。 Western Blot Analysis[1] Cell Line:

Name

CRA-026440 hydrochloride

CAS

847459-98-7

Formula

C23H25ClN4O4

Molar Mass

456.92

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

PeptideDB

CRA-026440 hydrochloride

CAS: 847459-98-7 F: C23H25ClN4O4 W: 456.92