| Bioactivity | CQ-Mito is a CQ-based derivative that exhibits profound phototherapeutic performances with an PI value of 167. CQ-Mito causes cell death by both apoptosis and ferroptosis. CQ-Mito mediated mitochondrial dysfunction, including mitochondrial morphology changed and the loss of MMP. CQ-Mito can efficiently inhibit the tumor growth using 3D multicellular tumor spheroids model[1]. |
| Formula | C45H42BrN6O4P |
| Molar Mass | 841.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhao X, et al. Coumarin-Quinazolinone based photosensitizers: Mitochondria and endoplasmic reticulum targeting for enhanced phototherapy via different cell death pathways. Eur J Med Chem. 2024 Dec 15;280:116990. |