| Bioactivity | CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM[1]. | ||||||||||||
| Target | IC50: 0. 0.63 µM (Keap1-Nrf2-ARE) | ||||||||||||
| Name | CPUY192018 | ||||||||||||
| CAS | 1567836-15-0 | ||||||||||||
| Formula | C28H26N2O10S2 | ||||||||||||
| Molar Mass | 614.64 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lee S, et al. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2022; 237:114380. |
CPUY192018
CAS: 1567836-15-0 F: C28H26N2O10S2 W: 614.64
CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependen
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