| Bioactivity | CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective[1]. |
| Invitro | CPUL1 (2.5, 5, 10, 20, 40 μM; 48 h) inhibits A549 cell proliferation and (2, 4, 8 μM; 48 h) colony formation[1].CPUL1 (4, 8 μM; 0, 24, 48 h) inhibits A549 cells migration and (2, 4, 8 μM; 48 h) invasion[1].CPUL1 hinders EMT (epithelial-mesenchymal transition) progress and affects MAPK pathway in A549 cells[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | CPUL1 |
| CAS | 2043660-80-4 |
| Formula | C22H13Cl2N5O |
| Molar Mass | 434.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |