CPF-7_product_DataBase

Bioactivity	CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes[1][2].
Invitro	CPF-7 (50 nM; 7 days) 将 PANC-1 外分泌细胞转化为胰腺内分泌前体细胞[1]。CPF-7 (3 µM; 20 min) 刺激 BRIN-BD11 大鼠克隆 β 细胞系中的胰岛素释放[2]。 Real Time qPCR[1] Cell Line:
Name	CPF-7
CAS	103238-06-8
Sequence	Gly-Phe-Gly-Ser-Phe-Leu-Gly-Lys-Ala-Leu-Lys-Ala-Ala-Leu-Lys-Ile-Gly-Ala-Asn-Ala-Leu-Gly-Gly-Ala-Pro-Gln-Gln
Shortening	GFGSFLGKALKAALKIGANALGGAPQQ
Formula	C118H193N33O32
Molar Mass	2586.00
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Heydari M, et al. Differentiation of PANC-1 ductal cells to β-like cells via cellular GABA modulation by Magainin and CPF-7 peptides. Biochem Biophys Res Commun. 2022 Feb 1;597:128-133. [2]. Srinivasan D, et al. Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. Biochimie. 2013 Feb;95(2):429-35.

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