| Bioactivity | CPD-10 is a potent CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-10 shows anti-proliferation. CPD-10 induces apoptosis. CPD-10 decreases the protein expression of cyclin D1, cyclin D 3, CDK4, P-Rb(5807/811) in a dose-dependent manner. (Pink: ligand for target protein (HY-50767); black: linker (HY-22391); Blue: E3 ligase ligand (HY-168667))[1]. |
| CAS | 3055471-57-0 |
| Formula | C46H61N15O4 |
| Molar Mass | 888.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jing Liu, et al. Compounds and methods of treating cancers. French, WO2024183798A1. |