| Bioactivity | CP-99994 hydrochloride is a high-affinity NK1 antagonist that exhibits the biological activity of preventing colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity. |
| CAS | 145148-39-6 |
| Formula | C19H26Cl2N2O |
| Molar Mass | 369.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice |
CP-99994 hydrochloride
CAS: 145148-39-6 F: C19H26Cl2N2O W: 369.33
CP-99994 hydrochloride is a high-affinity NK1 antagonist that exhibits the biological activity of preventing colorectal
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