| Bioactivity | CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. |
| Invitro | CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively[1]. |
| In Vivo | CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively[1]. |
| Name | CP-96486 |
| CAS | 139401-45-9 |
| Formula | C31H23ClN4O |
| Molar Mass | 502.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists. |
CP-96486
CAS: 139401-45-9 F: C31H23ClN4O W: 502.99
CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with K
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