| Bioactivity | CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1]. |
| In Vivo | In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED50s of 1.8 mg/kg p.o[1]. |
| Name | CP-96021 hydrochloride |
| CAS | 167011-22-5 |
| Formula | C29H22ClFN4OS |
| Molar Mass | 529.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A. Marfat, et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 1995, 5 (13): 1377-1382. |
CP-96021 hydrochloride
CAS: 167011-22-5 F: C29H22ClFN4OS W: 529.03
CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating facto
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