| Bioactivity | CP-20961 is a potent synthetic non-immunogenic adjuvant that induces arthritis[1][2]. |
| In Vivo | Avridine-induced arthritis is severe and long lasting in LEW and DA rats[2].CP-20961 (10 mg/kg, i.v., once either 24, 48, or 72 hours post-burn) had no effect on survival after challenge with P. aeruginosa 96 hours post-burn[3]. Animal Model: |
| Name | CP-20961 |
| CAS | 35607-20-6 |
| Formula | C43H90N2O2 |
| Molar Mass | 667.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Brun JG, et al. Effects of calprotectin in avridine-induced arthritis. APMIS. 1995 Mar;103(3):233-40. [2]. Vingsbo C, et al. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin Exp Immunol. 1995 Mar;99(3):359-63. [3]. Stinnett JD, et al. Synthetic immunomodulators for prevention of fatal infections in a burned guinea pig model. Ann Surg. 1983 Jul;198(1):53-7. |