| Bioactivity | CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration[1]. |
| Invitro | CP-195543 抑制由 LTB4 介导的人和小鼠中性粒细胞趋化性，IC50 值分别为 2.4 nM、7.5 nM[1]。CP-195543 (0.1 nM-10 µM；60 分钟) 阻断人中性粒细胞 (HN) 和小鼠中性粒细胞中 CD11b 的上调，对人单核细胞和嗜酸性粒细胞的 IC50 值分别为 270、420 nM [1]。 |
| In Vivo | CP-195543 (0.01, 0.1, 1, 10 mg/kg for guinea pig; 0.01, 0.1, 1, 10, 100 mg/kg for mice; P.o.; 1 h before injection of LTB4) 呈剂量依赖性抑制 LTB4 介导的中性粒细胞浸润[1]。 Animal Model: |
| Name | CP-195543 |
| CAS | 204981-48-6 |
| Formula | C24H19F3O4 |
| Molar Mass | 428.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Showell HJ, et al. The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543. J Pharmacol Exp Ther. 1998 Jun;285(3):946-54. |