CP 154526 hydrochloride_product_DataBase

Bioactivity	CP 154526 hydrochloride is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 hydrochloride has anxiolytic activities[1][2].
Invitro	CP 154526 hydrochloride 可取代大鼠海马 CRF 受体 (IC50 = 0.5 nM) 和垂体 CRF 受体 (IC50 = 0.04 nM) 中的 [125I][Tyr0]CRF[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CP 154526 hydrochloride 相关抗体:
In Vivo	CP 154526 (1-10 mg/kg；腹腔注射；一次) hydrochloride 在大鼠高架十字迷宫测试中表现出抗焦虑样活性迹象[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	257639-98-8
Formula	C23H33ClN4
Molar Mass	400.99
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. D W Schulz, et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10477-82. [2]. J Lundkvist, et al. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur J Pharmacol. 1996 Aug 8;309(2):195-200.

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