| Bioactivity | COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC50 value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with Ki value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties[1]. |
| Invitro | COX-2/PI3K-IN-2 (compound 5f) (50-500 µg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells[1].COX-2/PI3K-IN-2 (compound 5f) (10-150 µg/mL) has antioxidant properties with H2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition (IC50=3.25 nM)[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | COX-2/PI3K-IN-2 |
| Formula | C16H17N5O2 |
| Molar Mass | 311.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046. |