| Bioactivity | COX-2/15-LOX/mPGES-1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES-1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments[1]. |
| Name | COX-2/15-LOX/mPGES-1-IN-1 |
| Formula | C19H16N2O5 |
| Molar Mass | 352.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Elzahhar PA, et al. Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes. Eur J Med Chem. 2024 Jan 10;266:116138. |
COX-2/15-LOX/mPGES-1-IN-1
CAS: F: C19H16N2O5 W: 352.34
COX-2/15-LOX/mPGES-1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057,
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