| Bioactivity | COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities[1]. |
| CAS | 443790-30-5 |
| Formula | C25H21N3O3S |
| Molar Mass | 443.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Osman NA, et al. Dual COX-2 and 15-LOX inhibition study of novel 4-arylidine-2-mercapto-1-phenyl-1H-imidazolidin-5(4H)-ones: Design, synthesis, docking, and anti-inflammatory activity. Arch Pharm (Weinheim). 2024 Feb 5:e2300615. |
COX-2/15-LOX-IN-5
CAS: 443790-30-5 F: C25H21N3O3S W: 443.52
COX-2/15-LOX-IN-5 (Compound 4f) is adual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activa
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