| Bioactivity | COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity[1]. |
| Target | IC50: 0.068 μM (COX-2), 10.91 μM (COX-1), 2.29 μM (15-LOX) |
| Invitro | COX-2/15-LOX-IN-3 (compound 5k) decreases LPS-induced production of pro-inflammatory cytokines (IL-6, ROS, and NO) in RAW 264.7 macrophage cell line, with IC50s of 63.03 μM, 167.91 μM and 39.31 μM, respectively[1]. 0 --> COX-2/15-LOX-IN-3 相关抗体: |
| Name | COX-2/15-LOX-IN-3 |
| Formula | C25H24FN3O3S |
| Molar Mass | 465.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Elsayed S, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity. Eur J Med Chem. 2023 Aug 15;260:115724. |