COX-2-IN-34_product_DataBase

Bioactivity	COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects[1].
Invitro	COX-2-IN-34 (compound 8a) (100 μM, 24 h) 对 RAW264.7 细胞没有明显的细胞毒性[1]。COX-2-IN-34 选择性抑制 COX-1 和 COX-2 活性，其 IC50 分别为 34.86 和 0.42 μM。10 μM 的 COX-2-IN-34 对 COX-2 的抑制效果达到 82%[1]。 0 --> COX-2-IN-34 相关抗体:
In Vivo	COX-2-IN-34 (compound 8a) ( 口服, 50 mg/kg, 三天) 在正常雄性大鼠模型中无胃溃疡毒性[1]。COX-2-IN-34 (皮下注射, 50 mg/kg) 在卡拉胶诱导的大鼠足跖水肿实验模型中表现出明显的抗炎作用[1]。 Animal Model:
Name	COX-2-IN-34
CAS	2788578-71-0
Formula	C13H11NO4
Molar Mass	245.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. 1. 1.Min Xin, et al. Synthesis and biological evaluation of resveratrol amide derivatives as selective COX-2 inhibitors. Chemico-Biological Interactions. Volume 380, 1 August 2023, 110522.

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