| Bioactivity | COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1]. |
| Invitro | COX-2-IN-20 (Compound 5d) shows potential anti-inflammatory activity on NO inhibition in LPS-induced RAW 264.7 cell with an IC50 of 2.87 μM[1]. |
| In Vivo | COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin[1]. |
| Name | COX-2-IN-20 |
| CAS | 2529451-43-0 |
| Formula | C11H9ClFN3O2 |
| Molar Mass | 269.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li SM, et al. New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study. Bioorg Chem. 2020 Nov;104:104333. |
COX-2-IN-20
CAS: 2529451-43-0 F: C11H9ClFN3O2 W: 269.66
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows an
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