| Bioactivity | COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective binding at the active site of COX-2 co-crystal. COX-2-IN-14 exhibits a high level of in vivo anti-inflammatory activity, reducing ear edema and myeloperoxidase (MPO) activity in mice[1]. |
| Name | COX-2-IN-14 |
| CAS | 2428387-48-6 |
| Formula | C18H18N4O6 |
| Molar Mass | 386.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gonçalves DS, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorg Med Chem. 2020 Jun 15;28(12):115549. |
COX-2-IN-14
CAS: 2428387-48-6 F: C18H18N4O6 W: 386.36
COX-2-IN-14 (compound 2a) is a potent and selective COX-2 (cyclooxygenase-2) inhibitor. COX-2-IN-14 shows effective bind
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