| Bioactivity | COP1-ATGL modulator 1 (86) is an orally active modulator for COP1-ATGL axis. COP1-ATGL modulator 1 (86) could increase ATGL protein expression, reduce ATGL ubiquitination and COP1 autoubiquitination, and diminish lipid accumulation in hepatocytes in the nanomolar range[1]. |
| Name | COP1-ATGL modulator 1 |
| CAS | 2946701-09-1 |
| Formula | C27H33N5O5 |
| Molar Mass | 507.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dipayan Sarkar, et al. Discovery and Development of Quinazolinones and Quinazolinediones for Ameliorating Nonalcoholic Fatty Liver Disease (NAFLD) by Modulating COP1-ATGL Axis. J Med Chem. 2023 Dec 28;66(24):16728-16761. |
COP1-ATGL modulator 1
CAS: 2946701-09-1 F: C27H33N5O5 W: 507.58
COP1-ATGL modulator 1 (86) is an orally active modulator for COP1-ATGL axis. COP1-ATGL modulator 1 (86) could increase A
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