| Bioactivity | CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2]. |
| Invitro | CNDAC 有一个独特的作用机制: 进入 DNA 后，它诱导单链断裂 (SSBs)，当细胞经历第二个 S 期时，单链断裂 (SSBs) 转化为双链断裂 (DSBs)[1]。缺乏 Rad51D 和 XRCC3 可使细胞对 CNDAC (0-1 μM; 24 h) 敏感[1]。CNDAC (0-100 μM; 3 days) 抑制 HL-60 和 THP-1 细胞的增殖[2]。CNDAC (0-10 μM; 3-6 days) 诱导 HL-60 和 THP-1 细胞的凋亡[2]。CNDAC (6 μM; 48 h) 诱导 HCT116 细胞在延迟 S 期后的 G2 期停止细胞周期[3]。 Cell Viability Assay[1] Cell Line: |
| Name | CNDAC hydrochloride |
| CAS | 134665-72-8 |
| Formula | C10H13ClN4O4 |
| Molar Mass | 288.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
CNDAC hydrochloride
CAS: 134665-72-8 F: C10H13ClN4O4 W: 288.69
CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC h
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