| Bioactivity | CNBCA is a potent, selective, competitive SHP2 enzyme inhibitor, with the IC50 of 0.87 μM. CNBCA binds to full-length SHP2 and inhibits enzyme activity. CNBCA inhibits pAkt and pERK1/2, and the cell growth of BT474 and MDA-MB468 cells. CNBCA can be used for breast cancer study[1]. |
| Target | 0.87 μM (SHP2) |
| Invitro | CNBCA (0.25, 0.50, 1,2 μM, 48 h) 抑制 SHP2 介导的 BT474 和 MDA-MB468 细胞中 Akt 和ERK1/2 的激活，IC50 约为 1.0 μM[1]。CNBCA (500 nM, 24-72 h) 抑制 BT47 4和 MDA-MB468 细胞的生长[1]。 0 --> CNBCA 相关抗体: Western Blot Analysis[1] Cell Line: |
| Name | CNBCA |
| Formula | C26H34O5 |
| Molar Mass | 426.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dhanaji M, et al. Targeting SHP2 with an Active Site Inhibitor Blocks Signaling and Breast Cancer Cell Phenotypes. ACS Bio Med Chem Au 2023 |