| Bioactivity | CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development[1]. |
| Invitro | CMD178 (100 mM) suppresses IL-2-induced STAT5 phosphorylation and inhibits Foxp3 expression in T cells[1].CMD178 (100 mM) inhibits the development of Treg cells induced by IL2/sIL-2Rα signaling[1]. |
| Name | CMD178 |
| Formula | C7H7F2KOY |
| Molar Mass | 850.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Price-Troska T, et, al. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides. Invest New Drugs. 2019 Feb;37(1):9-16. |