| Bioactivity | (cis)-CM-414, the cis-isomer of CM-414, is a dual inhibitor of PDE5, HDAC1, HDAC2, HDAC3, and HDAC6 with pIC50 values of 7.47, 6.65, 6.14, 6.55, and 6.84, repectively[1]. |
| CAS | 1624792-70-6 |
| Formula | C23H29N5O4 |
| Molar Mass | 439.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mar Cuadrado-Tejedor, et al. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology. 2017 Jan;42(2):524-539. |